Bioethical Analysis of the Use of Genomic Biotechnology in Translational Nutrition
DOI:
https://doi.org/10.5294/pebi.2022.26.2.4Keywords:
Bioethics, person, nutritional genomics, freedom, truthAbstract
The advances in biotechnology and the fascinating perspectives of nutritional genomics in clinical practice have led to considering various aspects that impact the comprehensive benefit of the human being. Integrating personalized nutrition in clinical care requires a bioethical analysis focused on the person who, based on their unique nutrigenetic profile, contributes to health care through individualized nutritional treatment. The bioethical analysis contemplates the principles of therapeutic totality, freedom, and integrity. In addition, the use of nutrigenetic tests highlights not only the confidentiality of data, which is assumed, but also the right to privacy.
Downloads
References
Glass S, Fanzo J. Genetic modification technology for nutrition and improving diets: an ethical perspective. Curr Opin Biotechnol. 2017 apr 1;44:46–51. https://doi.org/10.1016/j.copbio.2016.11.005
Mathers JC. Nutrigenomics in the modern era. Proc Nutr Soc. 2017 ago 7;76(03):265-75. https://doi.org/10.1017/S002966511600080X
Duque RE. Capítulo IV. El derecho a la intimidad de la información genética. Ética biomédica Aspectos sociales de la biomedicina. EUNSA; Pamplona; 2019. p. 231-85.
Ordovas JM, Ferguson LR, Tai ES, Mathers JC. Personalised nutrition and health. BMJ. 2018 Jun 13;361:bmj.k2173. https://doi.org/10.1136/bmj.k2173
Kohlmeier M, De Caterina R, Ferguson LR, Görman U, Allayee H, Prasad C, et al. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016;9(1):28-46. https://doi.org/10.1159/000446347
Grimaldi KA, van Ommen B, Ordovas JM, Parnell LD, Mathers JC, Bendik I, et al. Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice. Genes Nutr. 2017;12(1):35. https://doi.org/10.1186/s12263-017-0584-0
Fenech M. Genome health nutrigenomics and nutrigenetics – diagnosis and nutritional treatment of genome damage on an individual basis. Food Chem Toxicol. 2008;46(4):1365-70. https://doi.org/10.1016/j.fct.2007.06.035
Ferguson LR, De Caterina R, Görman U, Allayee H, Kohlmeier M, Prasad C, et al. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016;9(1):12-27. https://doi.org/10.1159/000445350
Roqué MV, Macpherson I, Gonzalvo Cirac M. El principio de precaución y los límites en biomedicina. Persona y Bioética. 2015;19(1):129-39. https://doi.org/10.5294/pebi.2015.19.1.10
González AM. Naturaleza y dignidad personal desde el pensamiento de Robert Spaemann. El primado de la persona en la moral contemporánea: XVII Simposio Internacional de Teología de la Universidad de Navarra / edición dirigida por Augusto Sarmiento [et al.], Servicio de Publicaciones de la Universidad de Navarra, 1997, 215-224
Hesketh J. Personalised nutrition: how far has nutrigenomics progressed? Eur J Clin Nutr. 2012 oct 24;67:430. http://dx.doi.org/10.1038/ejcn.2012.145
Carbonell C, Flamarique L. De simios, cyborgs y dioses. Madrid: Editorial Biblioteca Nueva; 2016. págs. 1-284.
García Cuadrado JA. Antropología filosófica: una introducción a la filosofía del hombre. Pamplona: EUNSA; 2010. 15-255.
German-Zurriaráin R. Los límites éticos: ¿avance o retroceso? Persona y Bioética. 2017;21(2):233-42. https://doi.org/10.5294/pebi.2017.21.2.4
Yepes R. Fundamentos de Antropología: un ideal de la excelencia humana. Pamplona: EUNSA;1996. 1-373 .
Flores M, Glusman G, Brogaard K, Price ND, Hood L. P4 medicine: how systems medicine will transform the healthcare sector and society. Per Med. 2013;10(6):565–76. https://doi.org/10.2217/pme.13.57
Mathes WF, Kelly SA, Pomp D. Advances in comparative genetics: influence of genetics on obesity. Br J Nutr. 2011 oct;106 Suppl 1:S1-10. https://doi.org/10.1017/S0007114511001905
Lopez Moratalla N. Biología y ética de la bioética: la urgente necesidad de realismo. Cuad Bioética. 2013;24(2):251-64.
Sarah R. Se hace tarde y anochece. Madrid; PALABRA. 2019. 247-258.
San-Cristobal R, Milagro FI, Martínez JA. Future Challenges and Present Ethical Considerations in the Use of Personalized Nutrition Based on Genetic Advice. J Acad Nutr Diet. 2013;113(11):1447-54. http://dx.doi.org/10.1016/j.jand.2013.05.028
Fayos Febrer R. Personalist bioethics in the Romano Guardini’s thought. Cuad Bioet. 2014;25(83):159-68.
Spaemann R, Spaemann R. ¿Es todo ser humano una persona? Pers y derecho Rev Fundam las Inst Jurídicas y Derechos Humanos. 1997;(37):9-24.
Camp KM, Trujillo E. Position of the Academy of Nutrition and Dietetics: Nutritional Genomics. J Acad Nutr Diet. 2014 feb 1;114(2):299-312. https://doi.org/10.1016/j.jand.2013.12.001
Bernhardt BA, Zayac C, Gordon ES, Wawak L, Pyeritz RE, Gollust SE. Incorporating direct-to-consumer genomic information into patient care: attitudes and experiences of primary care physicians. Per Med. 2012 sep 1;9(7):683-92. https://doi.org/10.2217/pme.12.80
Bergmann MM, Bodzioch M, Bonet ML, Defoort C, Lietz G, Mathers JC. Bioethics in human nutrigenomics research: European Nutrigenomics Organisation workshop report. Br J Nutr. 2006;95(5):1024-1027. https://doi.org/10.1079/BJN20061758
Buitendijk GHS, Amin N, Hofman A, van Duijn CM, Vingerling JR, Klaver CCW. Direct-to-Consumer Personal Genome Testing for Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2014 oct 2;55(10):6167-74. https://doi.org/10.1167/iovs.14-15142
Janssens ACJW, Bunnik EM, Burke W, Schermer MHN. Uninformed consent in nutrigenomic research. Eur J Hum Genet. 2017 jul 10;25(7):789-90. https://doi.org/10.1038/ejhg.2017.63
Borry P, van Hellemondt RE, Sprumont D, Jales CFD, Rial-Sebbag E, Spranger TM, et al. Legislation on direct-to-consumer genetic testing in seven European countries. Eur J Hum Genet. 2012 jul 25;20(7):715-21. https://doi.org/10.1038/ejhg.2011.278
Lombo J. La persona y su naturaleza: Tomás de Aquino y Leonardo Polo. Anu Filosófico. 1996;29(55):721-39.
Dietrich L. La libertad humana como valor primordial en Tomás de Aquino. Teol y Vida. 2004;XLV:531-8.
Langley-Evans SC, McMullen S. Developmental origins of adult disease. Med Princ Pract. 2010;19(2):87-98. https://doi.org/10.1159/000273066
Duque RE. Capítulo V. Determinismo, indeterminismo y finalidad. Ética biomédica Aspectos sociales de la biomedicina. EUNSA, Pamplona; 2019. p. 287–350.
Goodarzi MO. Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol. 2017;6(3):223-36. https://doi.org/10.1016/S2213-8587(17)30200-0
de Roos B. Personalised nutrition: ready for practice? Proc Nutr Soc. 2013 feb 12;72(1):48-52. https://doi.org/10.1017/S0029665112002844
Thomas N. Beyond the Barker hypothesis and the thrifty genotype - The womb, ethnicity, genes and the environment - Recent perspectives on the evolution of diabetes and the metabolic syndrome in India. Indian J Endocrinol Metab. 2012 dic;16(Suppl 2):S142-6. https://doi.org/10.4103/2230-8210.104024
Walley AJ, Asher JE, Froguel P. The genetic contribution to non-syndromic human obesity. Nat Rev Genet. 2009;10(7):431-42. https://doi.org/10.1038/nrg2594
Thomassen Hammerstad G, Sarangi S, Bjørnevoll I. Diagnostic uncertainties, ethical tensions, and accounts of role responsibilities in genetic counseling communication. J Genet Couns. 2020;29(6):1159-1172. https://doi.org/10.1002/jgc4.1282
Fallaize R, Macready AL, Butler LT, Ellis JA, Lovegrove JA. An insight into the public acceptance of nutrigenomic-based personalised nutrition. Nutr Res Rev. 2013;26(1):39-48. https://doi.org/10.1017/S0954422413000024
Ramos-López O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, et al. Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J Nutrigenet Nutrigenomics. 2017;10(1-2):43-62. https://doi.org/10.1159/000477729
De Boo HA, Harding JE. The developmental origins of adult disease (Barker) hypothesis. Aust New Zeal J Obstet Gynaecol. 2006;46(1):4-14. https://doi.org/10.1111/j.1479-828X.2006.00506.x
Sols F. Certeza razonable en ciencia y filosofía. Sci Fides. 2016;4(2):483-99. https://doi.org/10.12775/SetF.2016.041
Álvarez-Martínez H, Pérez-Campos E. Causalidad en medicina. Gac Med Mex. 2004;140(4):467-72.
Santos JL, De la Cruz R, Holst C, Grau K, Naranjo C, Maiz A, et al. Allelic Variants of Melanocortin 3 Receptor Gene (MC3R) and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets. PLoS One. 2011 jun 14;6(6):e19934. https://doi.org/10.1371/journal.pone.0019934
Chang CS, Lu YJ, Chang HH, Hsu SH, Kuo PH, Shieh CC, et al. Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity. Obes Res Clin Pract. 2016;12(1):49-61. https://doi.org/10.1016/j.orcp.2016.05.003
Tan PY, Mitra SR, Amini F. Lifestyle Interventions for Weight Control Modified by Genetic Variation: A Review of the Evidence. Public Health Genomics. 2018;21(5-6):169-85. https://doi.org/10.1159/000499854
de Siqueira JE. El Principio De Responsabilidad De Hans Jonas. Acta Bioeth. 2001;7(2):277-85.
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ana Laura de la Garza, Yael Zonenszain-Laiter
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
This journal and its papers are published with the Creative Commons License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). You are free to share copy and redistribute the material in any medium or format if you: give appropriate credit, provide a link to the license, and indicate if changes were made; don’t use our material for commercial purposes; don’t remix, transform, or build upon the material.