Reflections about the Molecular Tool That Could Change the Course of Human History: Genome Editing
DOI:
https://doi.org/10.5294/pebi.2022.26.1.3Keywords:
Eugenics, designer babies, gene therapy, mutation, therapeutics, genetic engineeringAbstract
Genetic editing has many applications in almost all areas of society, but may also lead to unpredictable consequences. Genome editing to modify the human germline is at the center of global discussion. Owing to the increasing number of unanswered scientific, ethical, and policy questions, the scientific community agrees that it would be inappropriate to genetically modify embryos. A serious and open debate is necessary to decide whether such research should be suspended or encouraged. Here we show some bold arguments in favor of deleting deleterious genes from the human genome and the risks liberal eugenism poses.
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Pinello L, Canver MC, Hoban MD, Orkin SH, Kohn DB, Bauer DE, et al. Analyzing CRISPR genome-editing experiments with CRISPR. Nature Biotech. 2016;34:695–7. DOI: https://doi.org/10.1038/nbt.3583
Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. 2016;533(7603):420–4. DOI: https://doi.org/10.1038/nature17946
The Nuffield Council on Bioethics. Genome editing and human reproduction. Social and ethical issues; 2018. DOI: https://doi.org/10.1515/jwiet-2019-0012
Gyngell C, Bowman-Smart H, Savulescu J. Moral reasons to edit the human genome: Picking up from the Nuffield report. J Med Ethics. 2019;45(8):514–23. DOI: https://doi.org/10.1136/medethics-2018-105084
Gaskell G, Bard I, Allansdottir A, Vieira da Cunha R, Eduard P, Hampel J, et al. Public views on gene editing and its uses. Nature Biotech. 2017;35:1021-1023. DOI: https://doi.org/10.1038/nbt.3958
Hajiahmadi Z, Movahedi A, Wei H, Li D, Orooji Y, Ruan H, et al. Strategies to increase on-target and reduce off-target effects of the CRISPR/Cas9 system in plants. Int J Mol Sci. 2019;20(15):3719. DOI: https://doi.org/10.3390/ijms20153719
Li D, Zhou H, Zeng X. Battling CRISPR-Cas9 off-target genome editing. Cell Biol Toxicol. 2019;35:403–6. DOI: https://doi.org/10.1007/s10565-019-09485-5
Coelho MA, De Braekeleer E, Firth M, Bista M, Lukasiak S, Cuomo ME, et al. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs. Nat Commun. 2020;11(1):1–12. DOI: https://doi.org/10.1038/s41467-020-17952-5
Naeem M, Majeed S, Hoque MZ, Ahmad I. Latest developed strategies to minimize the off-target effects in CRISPR-Cas mediated genome editing. Cells. 2020;9(7):1608. DOI: https://doi.org/10.3390/cells9071608
Shevidi S, Uchida A, Schudrowitz N, Wessel GM, Yajima M. Single nucleotide editing without DNA cleavage using CRISPR/ Cas9-deaminase in the sea urchin embryo. Dev Dyn. 2017;246(12):1036–46. DOI: https://doi.org/10.1002/dvdy.24586
Chen C-L, Rodiger J, Chung V, Viswanatha R, Mohr SE, Hu Y, et al. SNP-CRISPR: a web tool for SNP-Specific genome editing. G3-Genes Genom Genet. 2020;10(2):489–94. DOI: https://doi.org/10.1534/g3.119.400904
Wang Y, Wang M, Zheng T, Hou Y, Zhang P, Tang T, et al. Specificity profiling of CRISPR system reveals greatly enhanced off-target gene editing. Sci Rep. 2020;10(1):1–8. DOI: https://doi.org/10.1038/s41598-020-58627-x
Miga KH, Koren S, Rhie A, Vollger MR, Gershman A, Bzikadze A, et al. Telomere-to-telomere assembly of a complete human X chromosome. Nature. 2020;585(7823):79–84. DOI: https://doi.org/10.1038/s41586-020-2547-7
Cohen J. Commission charts narrow path for editing human embryos. Science. 2020; DOI: https://doi.org/10.1126/science.abe6341
Ranisch R. Germline genome editing versus preimplantation genetic diagnosis: Is there a case in favour of germline interventions? Bioethics. 2020;34(1):60–9. DOI: https://doi.org/10.1111/bioe.12635
Mai LD, Saporiti AEL. Negative and positive eugenics: meanings and contradictions. Rev Latino-Am Enfermagem. 2006;14(2):251–9. DOI: https://doi.org/10.1590/S0104-11692006000200015
Arzheimer K. Secular citizens, pious MPs: why German attitudes about genetic testing are much more permissive than German laws. Polit Res Exch. 2020;2(1):1765693. DOI: https://doi.org/10.1080/2474736X.2020.1765693
Shaw J. Selecting for disabilities: selection versus modification. New Bioeth. 2018;24(1):44–56. DOI: https://doi.org/10.1080/20502877.2018.1441671
Rehmann-Sutter C. Why human germline editing is more problematic than selecting between embryos: Ethically Considering Intergenerational Relationships. New Bioeth. 2018;24(1):9–25. DOI: https://doi.org/10.1080/20502877.2018.1441669
Campeau PM, Foulkes WD, Tischkowitz MD. Hereditary breast cancer: New genetic developments, new therapeutic avenues. 2008;124:31–42. DOI: https://doi.org/10.1007/s00439-008-0529-1
Naciones Unidas. La Declaración Universal de Derechos Humanos. Available from: https://www.un.org/es/universal-declaration-human-rights/index.html
Savulescu J. Procreative beneficence: Why we should select the best children. In: Bioethics. Blackwell Publishing Ltd; 2001. p. 413–26. DOI: https://doi.org/10.1111/1467-8519.00251
Andorno R, Baylis F, Darnovsky M, Dickenson D, Haker H, Hasson K, et al. Geneva statement on heritable human genome editing: The Need for Course Correction. Trends Biotechnol.2020;38(4):351–4. DOI: https://doi.org/10.1016/j.tibtech.2019.12.022
Lander ES, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, et al. Adopt a moratorium on heritable genome editing. Nature. 2019;567(7747):165–8. DOI: https://doi.org/10.1038/d41586-019-00726-5
National Academy of Medicine, National Academy of Sciences, the RS. Heritable human genome editing. Washington, D.C.: National Academies Press; 2020. p. 224. DOI: https://doi.org/10.17226/25665
Dalege J, Borsboom D, van Harreveld F, van der Maas HLJ. The attitudinal entropy framework as a general theory of individual attitudes. Psychol Inq. 2018;29(4):175–93. DOI: https://doi.org/10.1080/1047840X.2018.1537246
Xavier MJ, Roman SD, Aitken RJ, Nixon B. Transgenerational inheritance: How impacts to the epigenetic and genetic information of parents affect offspring health. Hum Reprod Update. 2019;25(5):519–41. DOI: https://doi.org/10.1093/humupd/dmz017
Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res; 2007;61:5-10. DOI: https://doi.org/10.1203/pdr.0b013e318045bedb
Ramírez-Alarcón K, Sánchez-Agurto Á, Lamperti L, Martorell M. Epigenetics, maternal diet and metabolic programming. Open Biol J. 2019 Oct 18;7(1):45–51. DOI: https://doi.org/10.2174/1874196701907010045
Pentecost M, Meloni M. “It’s Never Too Early”: Preconception Care and Postgenomic Models of Life. Front Sociol. 2020;5:21. DOI: https://doi.org/10.3389/fsoc.2020.00021
Roseboom T, de Rooij S, Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006;82(8):485–91. DOI: https://doi.org/10.1016/j.earlhumdev.2006.07.001
Kuniyoshi KM, Hang B, Rehan VK. Early-life tobacco smoke/nicotine exposure and offspring health. In: Early-life Environmental Exposure and Disease. Singapore: Springer Singapore; 2020. p. 23–50. DOI: https://doi.org/10.1007/978-981-15-3797-4_2
Yankai X. Early-life Environmental Exposure and Disease. Xia Y, editor. Singapore: Springer Singapore; 2020. DOI: https://doi.org/10.1007/978-981-15-3797-4
Goubert D, Beckman WF, Verschure PJ, Rots MG. Epigenetic editing: towards realization of the curable genome concept. Converg Sci Phys Oncol. 2017;3(1):013006. DOI: https://doi.org/10.1088/2057-1739/aa5cc0
Datta Gupta N, Etcoff NL, Jaeger MM. Beauty in Mind: The Effects of physical attractiveness on psychological well-being and distress. J Happiness Stud. 2016;17(3):1313–25. DOI: https://doi.org/10.1111/maq.12025
Aquino YSJ. Is ugliness a pathology? An ethical critique of the therapeuticalization of cosmetic surgery. Bioethics. 2020;34(4):431–41. DOI: https://doi.org/10.1111/bioe.12721
Harari YN. Sapiens: Uma breve história da humanidade. L&PM. 2015. Available from: https://www.amazon.com.br/Sapiens-Uma-breve-história-humanidade-ebook/dp/B00UZLPCGQ
Caioli L. Messi: the inside story of the boy who became a legend. Thriplow: Corinthian; 2012. Available from: https://www.ebay.com/itm/Messi-The-Inside-Story-of-the-Boy-Who-Became-a-Legend-ExLibrary-/312484387280
Persaud A, Desine S, Blizinsky K, Bonham VL. A CRISPR focus on attitudes and beliefs toward somatic genome editing from stakeholders within the sickle cell disease community. Genet Med. 2018 Aug 1;21(8):1726-1734 DOI: https://doi.org/10.1038/s41436-018-0409-6
Juengst ET, Henderson GE, Walker RL, Conley JM, MacKay D, Meagher KM, et al. Is Enhancement the Price of Prevention in Human Gene Editing? Cris J. 2018;1(6):351–4. DOI: https://doi.org/10.1089/crispr.2018.0040
Blendon RJ, Gorski MT, Benson JM. The public and the Gene-editing revolution. N Engl J Med. 2016;1(6):1406–11. DOI: https://doi.org/10.1089/crispr.2018.0040l
Rosemann A, Balen A, Nerlich B, Hauskeller C, Sleeboom-Faulkner M, Hartley S, et al. Heritable genome editing in a global context: national and international policy challenges. Hastings Cent Rep. 2019;49(3):30–42. DOI: https://doi.org/10.1002/hast.1006
Halpern J, O’Hara SE, Doxzen KW, Witkowsky LB, Owen AL. Societal and ethical impacts of germline genome editing: how can we secure human rights? Cris J. 2019;2(5):293–8. DOI: https://doi.org/10.1089/crispr.2019.0042
Scheufele DA, Xenos MA, Howell EL, Rose KM, Brossard D, Hardy BW. U.S. attitudes on human genome editing. Science. 2017;357(6351):553–4. DOI: https://doi.org/10.1126/science.aan3708
Shew AM, Nalley LL, Snell HA, Nayga RM, Dixon BL. CRISPR versus GMOs: public acceptance and valuation. Glob Food Sec. 2018;19:71–80. DOI: https://doi.org/10.1016/j.gfs.2018.10.005
McCaughey T, Sanfilippo PG, Gooden GEC, Budden DM, Fan L, Fenwick E, et al. A global social media survey of attitudes to human genome editing. Cell Stem Cell. 2016 May 5;18(5): 569–72. DOI: https://doi.org/10.1016/j.stem.2016.04.011
Erich F. The art of Loving. The centennial edition A&C Black. 2000. 128 p. Available from: https://www.amazon.com/Erich-Fromm-Art-Loving-Inquiry/dp/B002278W40
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